CDK5 and ACTN1

Data Source:
HPRD (in vitro)

		CDK5	ACTN1
Description		cyclin dependent kinase 5	actinin alpha 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Neuron Projection Neuronal Cell Body Perikaryon Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Z Disc Platelet Alpha Granule Lumen Pseudopodium Cell Projection Extracellular Exosome Glutamatergic Synapse
	Molecular Function	P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Microtubule Binding Kinase Activity Protein Kinase Binding Acetylcholine Receptor Activator Activity ErbB-3 Class Receptor Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Hsp90 Protein Binding Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels Protein Serine Kinase Activity Protein Threonine Kinase Activity	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Nuclear Receptor Coactivator Activity Protein Homodimerization Activity Ion Channel Binding Actin Filament Binding Structural Constituent Of Postsynapse
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Neuron Migration Synaptic Transmission, Dopaminergic Protein Phosphorylation Intracellular Protein Transport Nucleocytoplasmic Transport Mitochondrion Organization Cell-matrix Adhesion Chemical Synaptic Transmission Axonogenesis Synapse Assembly Skeletal Muscle Tissue Development Motor Neuron Axon Guidance Visual Learning Response To Wounding Schwann Cell Development Synaptic Vesicle Exocytosis Regulation Of Macroautophagy Phosphorylation Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Corpus Callosum Development Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Cortical Actin Cytoskeleton Organization Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Positive Regulation Of Protein Binding Receptor Catabolic Process Positive Regulation Of Glial Cell Apoptotic Process Synaptic Transmission, Glutamatergic Protein Localization To Synapse Serine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Autophosphorylation Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Synapse Pruning Regulation Of Neurotransmitter Receptor Activity Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Neuron Death Positive Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization To Plasma Membrane Regulation Of Synaptic Vesicle Recycling Cellular Response To Amyloid-beta Positive Regulation Of Actin Cytoskeleton Reorganization	Platelet Degranulation Actin Filament Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Filament Network Formation Platelet Aggregation Postsynapse Organization
Pathways		DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 Factors involved in megakaryocyte development and platelet production	Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs		Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE	Human calcitonin Copper
Diseases
GWAS		Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)	Asthma ( 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) High light scatter reticulocyte count ( 32888494) Lack of perseverance ( 30718321) Mean platelet volume ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 26805783 29403010 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)
Interacting Genes		81 interacting genes: AATK ABL1 ACTN1 ALAS1 AMPH APP BAG6 CABLES1 CABLES2 CCND2 CCND3 CCNG1 CCNI CDC25A CDC25B CDC25C CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN FZR1 GAK GRIN2A GSK3B H1-0 H1-1 H1-5 HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A MEOX2 MIR9-1HG NDEL1 NEDD4 NEDD4L NES PAK1 PCNA PIKFYVE PIP5K1C PPARG PPP1R1B PPP1R2 PRKN PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SPDYA SPDYE4 SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 TRIM59 WASF1 YBX3	90 interacting genes: ACTN2 ACTN3 ADORA2A APC APPBP2 ATXN2 ATXN7 C14orf119 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS DYNLT1 EIF2S1 EPM2AIP1 ERBIN FBP1 FXN GADD45G GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LINC01554 LNX1 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NKAPD1 NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP SYNPO2L TES TTN TXN USP2 VCL XRCC4 ZYX
Entrez ID		1020	87
HPRD ID		00449	00020
Ensembl ID		ENSG00000164885	ENSG00000072110
Uniprot IDs		A0A090N7W4 A0A0S2Z355 Q00535	A0A024R694 P12814
PDB IDs		1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8	2EYI 2EYN 2N8Y 2N8Z
Enriched GO Terms of Interacting Partners?
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