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CDK5 and ACTN1
Data Source:
HPRD
(in vitro)
CDK5
ACTN1
Description
cyclin dependent kinase 5
actinin alpha 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Lamellipodium
Cell Junction
Filopodium
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Perikaryon
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Stress Fiber
Ruffle
Extracellular Region
Extracellular Space
Cytoplasm
Cytosol
Actin Filament
Plasma Membrane
Brush Border
Cell-cell Junction
Fascia Adherens
Focal Adhesion
Z Disc
Platelet Alpha Granule Lumen
Pseudopodium
Cell Projection
Extracellular Exosome
Glutamatergic Synapse
Molecular Function
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
ErbB-2 Class Receptor Binding
Protein Binding
ATP Binding
Microtubule Binding
Kinase Activity
Protein Kinase Binding
Acetylcholine Receptor Activator Activity
ErbB-3 Class Receptor Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Hsp90 Protein Binding
Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Double-stranded RNA Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Vinculin Binding
Nuclear Receptor Coactivator Activity
Protein Homodimerization Activity
Ion Channel Binding
Actin Filament Binding
Structural Constituent Of Postsynapse
Biological Process
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Neuron Migration
Synaptic Transmission, Dopaminergic
Protein Phosphorylation
Intracellular Protein Transport
Nucleocytoplasmic Transport
Mitochondrion Organization
Cell-matrix Adhesion
Chemical Synaptic Transmission
Axonogenesis
Synapse Assembly
Skeletal Muscle Tissue Development
Motor Neuron Axon Guidance
Visual Learning
Response To Wounding
Schwann Cell Development
Synaptic Vesicle Exocytosis
Regulation Of Macroautophagy
Phosphorylation
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cerebellar Cortex Formation
Hippocampus Development
Layer Formation In Cerebral Cortex
Central Nervous System Neuron Development
Corpus Callosum Development
Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Cortical Actin Cytoskeleton Organization
Neuron Projection Development
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Synaptic Plasticity
Positive Regulation Of Protein Binding
Receptor Catabolic Process
Positive Regulation Of Glial Cell Apoptotic Process
Synaptic Transmission, Glutamatergic
Protein Localization To Synapse
Serine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Calcium Ion-dependent Exocytosis
Protein Autophosphorylation
Negative Regulation Of Protein Export From Nucleus
Behavioral Response To Cocaine
Regulation Of Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Rhythmic Process
Axon Extension
Oligodendrocyte Differentiation
Dendrite Morphogenesis
Cell Division
Neuron Apoptotic Process
Regulation Of Synaptic Transmission, Glutamatergic
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Morphogenesis
Calcium Ion Import
Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Synapse Pruning
Regulation Of Neurotransmitter Receptor Activity
Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Negative Regulation Of Neuron Death
Positive Regulation Of Voltage-gated Calcium Channel Activity
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Protein Localization To Plasma Membrane
Regulation Of Synaptic Vesicle Recycling
Cellular Response To Amyloid-beta
Positive Regulation Of Actin Cytoskeleton Reorganization
Platelet Degranulation
Actin Filament Organization
Platelet Activation
Platelet Formation
Platelet Morphogenesis
Regulation Of Apoptotic Process
Positive Regulation Of Transcription, DNA-templated
Focal Adhesion Assembly
Actin Filament Bundle Assembly
Negative Regulation Of Cellular Component Movement
Actin Filament Network Formation
Platelet Aggregation
Postsynapse Organization
Pathways
DARPP-32 events
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
Factors involved in megakaryocyte development and platelet production
Platelet degranulation
Syndecan interactions
Nephrin family interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Human calcitonin
Copper
Diseases
GWAS
Eyebrow thickness (
26926045
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Asthma (
31959851
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Feeling fed-up (
29500382
)
Feeling hurt (
29500382
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
)
High light scatter reticulocyte count (
32888494
)
Lack of perseverance (
30718321
)
Mean platelet volume (
32888494
27863252
)
Medication use (drugs used in diabetes) (
31015401
)
Mosquito bite size (
28199695
)
Neurociticism (
29500382
)
Periodontitis (Mean PAL) (
24024966
)
Platelet count (
26805783
29403010
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Prostate cancer (
23535732
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Smoking behavior (
19247474
)
Urinary albumin excretion (
30220432
)
Interacting Genes
81 interacting genes:
AATK
ABL1
ACTN1
ALAS1
AMPH
APP
BAG6
CABLES1
CABLES2
CCND2
CCND3
CCNG1
CCNI
CDC25A
CDC25B
CDC25C
CDC37
CDK16
CDK5R1
CDK5R2
CDK5RAP1
CDK5RAP2
CDKN1B
CHN1
CSNK1D
DAB1
DCX
DNM1
ERBB3
EZR
FSD1
FYN
FZR1
GAK
GRIN2A
GSK3B
H1-0
H1-1
H1-5
HTRA2
KIF26B
LMTK2
MAP2K1
MAPK10
MAPT
MAST1
MBP
MEF2A
MEOX2
MIR9-1HG
NDEL1
NEDD4
NEDD4L
NES
PAK1
PCNA
PIKFYVE
PIP5K1C
PPARG
PPP1R1B
PPP1R2
PRKN
PSEN1
PTPN2
PURA
RB1
RNF32
RPL34
SET
SPDYA
SPDYE4
SRC
STX1A
STXBP1
SYN1
SYNJ1
TLN1
TP53
TRIM59
WASF1
YBX3
90 interacting genes:
ACTN2
ACTN3
ADORA2A
APC
APPBP2
ATXN2
ATXN7
C14orf119
CACNA1A
CAMK2A
CBY2
CDK5
CDK5R1
CDK5R2
CLIC5
COIL
COL17A1
CSRP1
CSRP3
CTNNA1
DDIAS
DYNLT1
EIF2S1
EPM2AIP1
ERBIN
FBP1
FXN
GADD45G
GFI1B
GIPC1
GIT2
GRIA4
GRIN2A
GRM5
GTF2H1
HSPB1
ICAM5
ITGB1
KAT2B
KCTD6
KPNA2
LINC01554
LNX1
LPP
MAGEA11
MAP2
MAP3K1
MED14
MICALL2
MTDH
MTNR1A
MTNR1B
MYOT
MYOZ1
MYOZ2
MYOZ3
NEBL
NKAPD1
NR1H3
NUMBL
OAS1
PALLD
PDHX
PDLIM1
PDLIM5
PIAS4
PKD1
PKN1
PLD2
PSEN1
PSMA1
PTK2
PTPN1
PTPN6
PYGB
RAVER1
RPS27
SIRPA
SLC2A4
SORBS2
SRC
SSX2IP
SYNPO2L
TES
TTN
TXN
USP2
VCL
XRCC4
ZYX
Entrez ID
1020
87
HPRD ID
00449
00020
Ensembl ID
ENSG00000164885
ENSG00000072110
Uniprot IDs
A0A090N7W4
A0A0S2Z355
Q00535
A0A024R694
P12814
PDB IDs
1H4L
1LFR
1UNG
1UNH
1UNL
3O0G
4AU8
2EYI
2EYN
2N8Y
2N8Z
Enriched GO Terms of Interacting Partners
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