TARBP2 and KRT5

		TARBP2	KRT5
Description		TARBP2 subunit of RISC loading complex	keratin 5
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Protein N-terminus Binding Pre-miRNA Binding	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Translation Negative Regulation Of Protein Kinase Activity Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Positive Regulation Of Viral Genome Replication Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Regulation Of Production Of SiRNA Involved In RNA Interference Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Cytoskeleton Organization Epidermis Development
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Basal cell carcinoma ( 31174203 33549134 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		30 interacting genes: ADARB1 AGO2 APP DICER1 EIF2AK2 HDHD2 HSPB1 IKBKG KCNIP3 KRT5 KRT6A MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NUDT18 OGT PNKP PRKRA RBM14 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346	35 interacting genes: ALOX12 ALOX12B APC DCTN1 DSP DST EVPL GPD1 INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT4 KRT40 KRT6A KRT6B KRT7 NADSYN1 PKP2 SAP18 SORD TARBP2 TCHP UBE3A
Entrez ID		6895	3852
HPRD ID		05446	01010
Ensembl ID		ENSG00000139546	ENSG00000186081
Uniprot IDs		A0A024RB49 Q15633	P13647
PDB IDs		2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM	3TNU 6JFV
Enriched GO Terms of Interacting Partners?
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