KRT5 and SAP18

		KRT5	SAP18
Description		keratin 5	Sin3A associated protein 18
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck ASAP Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Transcription Corepressor Activity RNA Binding Protein Binding Transcription Factor Binding
	Biological Process	Cytoskeleton Organization Epidermis Development	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	HDACs deacetylate histones NoRC negatively regulates rRNA expression Potential therapeutics for SARS
Drugs		Zinc Zinc acetate
Diseases
GWAS		Basal cell carcinoma ( 31174203 33549134 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		35 interacting genes: ALOX12 ALOX12B APC DCTN1 DSP DST EVPL GPD1 INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT4 KRT40 KRT6A KRT6B KRT7 NADSYN1 PKP2 SAP18 SORD TARBP2 TCHP UBE3A	17 interacting genes: DEF6 ERBB3 HDAC1 IFT88 IKZF1 INCA1 KRT5 NOL12 NTAQ1 POLE2 RBM39 RNPS1 RPS3A SIN3A SUFU TADA3 TSC22D2
Entrez ID		3852	10284
HPRD ID		01010	04256
Ensembl ID		ENSG00000186081	ENSG00000150459
Uniprot IDs		P13647	O00422
PDB IDs		3TNU 6JFV	2HDE
Enriched GO Terms of Interacting Partners?
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