RAP2B and RAP1GDS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RAP2B	RAP1GDS1
Description		RAP2B, member of RAS oncogene family	Rap1 GTPase-GDP dissociation stimulator 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding	GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways		Neutrophil degranulation	RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		10 interacting genes: CAMK2B PDE6D PRKAR2B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451
Entrez ID		5912	5910
HPRD ID		01548	11763
Ensembl ID		ENSG00000181467	ENSG00000138698
Uniprot IDs		P61225	B3KNU0 P52306 Q6U7G8
PDB IDs		1N4P 1N4Q 1N4R	5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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