RAP1GDS1 and PLEKHB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RAP1GDS1	PLEKHB1
Description		Rap1 GTPase-GDP dissociation stimulator 1	pleckstrin homology domain containing B1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Cytoplasm Integral Component Of Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding
	Biological Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Phototransduction Regulation Of Cell Differentiation
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Dimensional psychopathology (Cognitive) ( 29496196) Glucose homeostasis traits ( 25524916) Hand grip strength ( 27325353) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451	13 interacting genes: ACVR1 ATXN1 BAG3 BMPR1B C10orf55 CCR8 GLIS2 GNGT1 RAP1GDS1 SMAD1 TGFBR1 VENTX ZDHHC17
Entrez ID		5910	58473
HPRD ID		11763	09630
Ensembl ID		ENSG00000138698	ENSG00000021300
Uniprot IDs		B3KNU0 P52306 Q6U7G8	A0A024R5H7 A0A024R5H9 A0A024R5J2 Q9UF11
PDB IDs		5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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