RAP2B and PRKAR2B

		RAP2B	PRKAR2B
Description		RAP2B, member of RAS oncogene family	protein kinase cAMP-dependent type II regulatory subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Fatty Acid Metabolic Process Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Response To Clozapine Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Neutrophil degranulation	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: CAMK2B PDE6D PRKAR2B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	26 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 C2orf88 CBR1 CFAP91 ECM1 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA OGT PAK1IP1 RAP2B RPL30 TAF12 TFR2
Entrez ID		5912	5577
HPRD ID		01548	01486
Ensembl ID		ENSG00000181467	ENSG00000005249
Uniprot IDs		P61225	A0A024R712 B3KY43 P31323
PDB IDs		1N4P 1N4Q 1N4R
Enriched GO Terms of Interacting Partners?
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