RAP1GDS1 and DIRAS2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RAP1GDS1	DIRAS2
Description		Rap1 GTPase-GDP dissociation stimulator 1	DIRAS family GTPase 2
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Signal Transduction Positive Regulation Of MAP Kinase Activity
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Cognitive test performance ( 17903297) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Multiple sclerosis ( 31604244) Protein quantitative trait loci ( 18464913)
Interacting Genes		28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451	3 interacting genes: RAP1GDS1 RIPPLY1 UNC45A
Entrez ID		5910	54769
HPRD ID		11763	09711
Ensembl ID		ENSG00000138698	ENSG00000165023
Uniprot IDs		B3KNU0 P52306 Q6U7G8	Q96HU8
PDB IDs		5XGC 5ZHX	2ERX 6NAZ
Enriched GO Terms of Interacting Partners?
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