RAP1GDS1 and MED28

		RAP1GDS1	MED28
Description		Rap1 GTPase-GDP dissociation stimulator 1	mediator complex subunit 28
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Nucleoplasm Membrane Mediator Complex Cortical Actin Cytoskeleton
	Molecular Function	GTPase Activator Activity Protein Binding	Actin Binding Protein Binding
	Biological Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Stem Cell Population Maintenance Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451	20 interacting genes: CBY2 FYN GRB2 GRPEL1 HSP90AA1 KLHL12 LCK MAGEA11 MED30 MED8 MED9 MIIP NF2 PRMT6 PUF60 RAP1GDS1 SRC SUOX TCP11 USHBP1
Entrez ID		5910	80306
HPRD ID		11763	14381
Ensembl ID		ENSG00000138698	ENSG00000118579
Uniprot IDs		B3KNU0 P52306 Q6U7G8	Q9H204
PDB IDs		5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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