PAK6 and KNL1

		PAK6	KNL1
Description		p21 (RAC1) activated kinase 6	kinetochore scaffold 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Cell Junction	Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Anxiety and stress-related disorders ( 31116379) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		28 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1	7 interacting genes: BUB1 BUB1B DSN1 MIS12 PAK6 PPP1CA TTK
Entrez ID		56924	57082
HPRD ID		06426	10634
Ensembl ID		ENSG00000137843	ENSG00000137812
Uniprot IDs		A0A024R9Q4 Q9NQU5	Q8NG31
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS	3SI5 4A1G 4NF9 4NFA
Enriched GO Terms of Interacting Partners?
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