PAK6 and LIMK1

Number of citations of the paper that reports this interaction (PubMedID 26375402)
21

Data Source:
BioGRID (enzymatic study)

		PAK6	LIMK1
Description		p21 (RAC1) activated kinase 6	LIM domain kinase 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Cell Junction	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Neuron Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Axon Extension Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs		Fostamatinib	Dabrafenib Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		28 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1	32 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 C22orf15 C5 CDC42BPA CDKN1C CFL1 CFL2 FBXO7 H1-1 LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SELENOS SRPK1 SSH3 WASHC1 YWHAZ
Entrez ID		56924	3984
HPRD ID		06426	03210
Ensembl ID		ENSG00000137843	ENSG00000106683
Uniprot IDs		A0A024R9Q4 Q9NQU5	P53667
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS	3S95 5HVJ 5HVK 5L6W 5NXC 6WLY 7ATS 7ATU
Enriched GO Terms of Interacting Partners?
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