PAK6 and GJD2

		PAK6	GJD2
Description		p21 (RAC1) activated kinase 6	gap junction protein delta 2
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Cell Junction	Plasma Membrane Connexin Complex Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity	Gap Junction Channel Activity
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension	Cell-cell Signaling Transmembrane Transport
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	Electric Transmission Across Gap Junctions Gap junction assembly
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Axial length ( 25823570 24144296) Congenital left-sided heart lesions ( 25138779) High myopia ( 31816047 32428537) Hyperopia ( 25233373) Myopia ( 27182965 25233373) Refractive error ( 23396134 32231278 20835239) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		28 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1	3 interacting genes: LNX1 LNX2 PAK6
Entrez ID		56924	57369
HPRD ID		06426	09521
Ensembl ID		ENSG00000137843	ENSG00000159248
Uniprot IDs		A0A024R9Q4 Q9NQU5	A0A654IE23 Q9UKL4
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS	2N6A
Enriched GO Terms of Interacting Partners?
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