KNL1 and BUB1B

Number of citations of the paper that reports this interaction (PubMedID 20220147)
20

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		KNL1	BUB1B
Description		kinetochore scaffold 1	BUB1 mitotic checkpoint serine/threonine kinase B
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GO Annotations	Cellular Component	Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body	Kinetochore Outer Kinetochore Anaphase-promoting Complex Cytoplasm Microtubule Organizing Center Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Signaling Mitotic Spindle Assembly Checkpoint Signaling Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Chronic lymphocytic leukemia ( 28165464 24292274)
Interacting Genes		7 interacting genes: BUB1 BUB1B DSN1 MIS12 PAK6 PPP1CA TTK	25 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DNMBP FBXO7 HDAC1 KNL1 MAP3K4 PELI1 PLK1 RIPK3 SNCG TP73 TRIP13
Entrez ID		57082	701
HPRD ID		10634	04176
Ensembl ID		ENSG00000137812	ENSG00000156970
Uniprot IDs		Q8NG31	O60566
PDB IDs		3SI5 4A1G 4NF9 4NFA	2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?
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