ASGR2 and CERS2

Number of citations of the paper that reports this interaction (PubMedID 11543633)
15

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ASGR2	CERS2
Description		asialoglycoprotein receptor 2	ceramide synthase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Glycoprotein Metabolic Process Bone Mineralization Regulation Of Protein Stability Lipid Homeostasis	Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Pathways		Asparagine N-linked glycosylation	Sphingolipid de novo biosynthesis
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Blood protein levels ( 29875488) Congenital heart disease (maternal effect) ( 28468790) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Total cholesterol levels ( 30275531)	Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Estimated glomerular filtration rate ( 31152163 31015462) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 34059833 28898252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		51 interacting genes: ADAM33 ADIPOQ AIG1 ASGR1 ATP6V0C BET1 CD53 CERS2 CLEC17A CLEC7A CTNNB1 EMP1 F8 FA2H FATE1 GLP1R GLUD1 HES1 HMOX2 HNF1B IL1RL1 LAT LNPEP MCEMP1 MMD2 MROH5 MS4A13 NRG1 ORMDL1 PLN PLP2 PMP22 RPRM SEC22A SLC35A1 SLC35B2 SMIM3 STX8 TFRC TMEM140 TMEM60 TMEM86B TMPPE TRAM1L1 TSPO2 UBIAD1 UPK2 VAMP5 VKORC1 VTI1B YIPF1	14 interacting genes: ASGR1 ASGR2 ATP6V0C DRD2 HSP90AA1 IER3IP1 NFE2L2 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 TNFSF4 YIF1A
Entrez ID		433	29956
HPRD ID		00152	06080
Ensembl ID		ENSG00000161944	ENSG00000143418
Uniprot IDs		P07307 Q7Z4G9	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?
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