GHSR and SIGMAR1

Number of citations of the paper that reports this interaction (PubMedID 29876881)
3

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GHSR	SIGMAR1
Description		growth hormone secretagogue receptor	sigma non-opioid intracellular receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Neuron Projection Membrane Raft Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Integral Component Of Synaptic Membrane	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Postsynaptic Density Membrane Integral Component Of Membrane Growth Cone Cytoplasmic Vesicle Postsynaptic Density Membrane
	Molecular Function	Growth Hormone Secretagogue Receptor Activity G Protein-coupled Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding	G Protein-coupled Opioid Receptor Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Spermatogenesis Learning Or Memory Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Response To Food Negative Regulation Of Appetite Positive Regulation Of Appetite Response To Follicle-stimulating Hormone Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Ghrelin Secretion Positive Regulation Of Multicellular Organism Growth Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Regulation Of Growth Hormone Secretion Response To Growth Hormone Cellular Response To Lipopolysaccharide Response To Dexamethasone Negative Regulation Of Locomotion Involved In Locomotory Behavior Cellular Response To Thyroid Hormone Stimulus Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Response To Monosodium Glutamate Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Macrophage Apoptotic Process	Lipid Transport Nervous System Development Cell Death In Response To Hydrogen Peroxide G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Potential therapeutics for SARS
Drugs		Ulimorelin Macimorelin Echinacoside	Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Noscapine Captodiame Pentoxyverine
Diseases
GWAS		Chronotype ( 30696823) Cocaine dependence ( 31212010) Height ( 20881960 25282103 25429064 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: CORT DRD1 GHRL SIGMAR1	14 interacting genes: ANK2 DCAF12 DNAJB5 GHSR GNE ITPR3 NFX1 PDZD11 PHF24 RECK RUSC2 SPAG8 SPINK4 VCP
Entrez ID		2693	10280
HPRD ID		03541	03580
Ensembl ID		ENSG00000121853	ENSG00000147955
Uniprot IDs		Q92847	A2A3U5 B4DR71 Q99720
PDB IDs		6KO5	5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?
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