SH3BP1 and NGLY1

		SH3BP1	NGLY1
Description		SH3 domain binding protein 1	N-glycanase 1
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GO Annotations	Cellular Component	Phagocytic Cup Intracellular Anatomical Structure Nucleus Cytosol Adherens Junction Bicellular Tight Junction Lamellipodium Cell Leading Edge	Nucleus Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding Semaphorin Receptor Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Phagocytosis, Engulfment Actin Filament Organization Cell Migration Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Regulation Of Rac Protein Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation ER-associated Misfolded Protein Catabolic Process
Pathways		RAC1 GTPase cycle	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS
Interacting Genes		16 interacting genes: ABI2 ABI3 ABL1 CCDC146 CRK FGA HCK NGLY1 POT1 RAC1 RHOA SRC SUN2 SYNJ1 TERF1 TRIP10	25 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID		23616	55768
HPRD ID		10227	10118
Ensembl ID		ENSG00000100092	ENSG00000151092
Uniprot IDs		A0A2X0SFX7 Q9Y3L3	Q96IV0
PDB IDs		4J9D 4J9F	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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