NGLY1 and OPA3

		NGLY1	OPA3
Description		N-glycanase 1	outer mitochondrial membrane lipid metabolism regulator OPA3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation ER-associated Misfolded Protein Catabolic Process	Visual Perception Regulation Of Lipid Metabolic Process Response To Stimulus
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS			Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Depression and alcohol dependence ( 22064162)
Interacting Genes		25 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC	6 interacting genes: APP KDM1A NGLY1 PRMT6 SUV39H1 UBC
Entrez ID		55768	80207
HPRD ID		10118	05956
Ensembl ID		ENSG00000151092	ENSG00000125741
Uniprot IDs		Q96IV0	B4DK77 Q9H6K4
PDB IDs		2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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