NGLY1 and MAP3K2

		NGLY1	MAP3K2
Description		N-glycanase 1	mitogen-activated protein kinase kinase kinase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytosol
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation ER-associated Misfolded Protein Catabolic Process	MAPK Cascade Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs			Bosutinib Fostamatinib
Diseases
GWAS			Protein C levels ( 28082259)
Interacting Genes		25 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC	25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ
Entrez ID		55768	10746
HPRD ID		10118	10068
Ensembl ID		ENSG00000151092	ENSG00000169967
Uniprot IDs		Q96IV0	A0A024RAH0 Q9Y2U5
PDB IDs		2CCQ 2CM0	2CU1 2NPT 5EX0 5HQ8
Enriched GO Terms of Interacting Partners?
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