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NGLY1

Description N-glycanase 1
Image
GO Annotations Cellular Component
  • Nucleus
  • Cytoplasm
  • Cytosol
Molecular Function
  • Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity
  • Protein Binding
  • Metal Ion Binding
Biological Process
  • Protein Folding
  • Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
  • Glycoprotein Catabolic Process
  • Protein Deglycosylation
  • ER-associated Misfolded Protein Catabolic Process
Pathways
  • N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS
Interacting Genes 25 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID 55768
HPRD ID 10118
Ensembl ID ENSG00000151092
Uniprot IDs Q96IV0
PDB IDs 2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025