HCLS1 and ZBTB25

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		HCLS1	ZBTB25
Description		hematopoietic cell-specific Lyn substrate 1	zinc finger and BTB domain containing 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm Mitochondrion Cytosol Actin Filament Plasma Membrane Postsynaptic Density Lamellipodium Dendrite Site Of Polarized Growth Cortical Actin Cytoskeleton Postsynaptic Membrane	Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Factor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Actin Filament Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Cytokine Stimulus Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization	Regulation Of Transcription, DNA-templated Gene Expression
Pathways
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252)
Interacting Genes		23 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	22 interacting genes: APIP COIL CYP2J2 DDIT3 FCGR3A FHL2 HCLS1 KCTD1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 SUMO2 TNIP1 TRAF2 TSSK3 ZBTB1
Entrez ID		3059	7597
HPRD ID		03199	01926
Ensembl ID		ENSG00000180353	ENSG00000089775
Uniprot IDs		P14317	G3V2K3 P24278
PDB IDs
Enriched GO Terms of Interacting Partners?
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