CLOCK and PPP1CB

Number of citations of the paper that reports this interaction (PubMedID 23555304)
16

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CLOCK	PPP1CB
Description		clock circadian regulator	protein phosphatase 1 catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Chromosome Cytosol Chromatoid Body Intracellular Membrane-bounded Organelle	Protein Phosphatase Type 1 Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Glycogen Granule Extracellular Exosome PTW/PP1 Phosphatase Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity
	Biological Process	DNA Damage Checkpoint Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Acetylation Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Histone Acetylation Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Cell Division
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression HATs acetylate histones Circadian Clock	Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Height ( 25282103) Personality dimensions ( 18957941) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 30598549 28869591) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)
Interacting Genes		27 interacting genes: ARNTL ARNTL2 BHLHE41 CEP135 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B NPAS2 PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1	30 interacting genes: AATK ACTN2 AURKA BRCA1 CLK1 CLOCK CSNK2B CSRNP2 DELEC1 FBXO7 H3-3A H3C1 LMTK2 MAPT NONO PPP1R12B PPP1R12C PPP1R16A PPP1R16B PPP1R2B PPP1R9B PPP2R5C PRKAR2A PTK2 RB1 RORC SH2D4A TLX1 WBP11 ZFYVE9
Entrez ID		9575	5500
HPRD ID		03508	11792
Ensembl ID		ENSG00000134852	ENSG00000213639
Uniprot IDs		O15516 Q3ZCT4 Q53EU0	P62140 V9HW04
PDB IDs		4H10 6QPJ
Enriched GO Terms of Interacting Partners?
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