ATG5 and CCHCR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ATG5	CCHCR1
Description		autophagy related 5	coiled-coil alpha-helical rod protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytosol Axoneme Membrane Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated ER Membrane	Nucleus Centriole Cytosol
	Molecular Function	Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Blood Vessel Remodeling Regulation Of Cytokine Secretion Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Fungus Macroautophagy Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Autophagy Of Nucleus Negative Thymic T Cell Selection Otolith Development Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Negative Regulation Of Cell Death Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Autophagy Of Host Cells Involved In Interaction With Symbiont Regulation Of Cilium Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation	Protein Export From Nucleus Multicellular Organism Development Cell Differentiation
Pathways		Macroautophagy Macroautophagy Pink/Parkin Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 27363682) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 31672989) Visceral fat ( 30942860)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Feeling nervous ( 29500382) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Multiple myeloma ( 23955597) Nevirapine-induced rash ( 21810746) Night sleep phenotypes ( 27126917) Prostate cancer ( 21743467) Psoriasis ( 30921485) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) White blood cell count ( 21738480)
Interacting Genes		17 interacting genes: ATG10 ATG12 ATG16L1 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD KEAP1 MEOX2 OPTN RAB33B RACK1 TECPR1 TEKT4 VCP WDFY3	62 interacting genes: ABI2 ALAS1 AMOTL2 ATG5 BLOC1S6 C1orf94 CARD9 CBY2 CCDC102B CCDC136 CDR2 CEP55 CNN1 COG6 EFHC2 FSD2 GLRX3 GOLGA2 GRAP2 HAUS1 HSBP1 HSPB1 IKBKG KRT13 KRT15 KRT31 KRT40 MAD1L1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NINL NME7 NUP62 NUTM1 PCM1 PIAS2 POLD2 POLR2C PRKCG RBM17 SAT1 SPAG5 SSX2IP STAR TADA2A TEKT1 TFIP11 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TSGA10 TXLNA TXLNB USHBP1 WASHC3 ZFYVE19
Entrez ID		9474	54535
HPRD ID		16051	05607
Ensembl ID		ENSG00000057663	ENSG00000204536
Uniprot IDs		A9UGY9 Q7Z3H3 Q9H1Y0	A0A1U9X7G6 Q2TB68 Q769H0 Q8TD31
PDB IDs		4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW
Enriched GO Terms of Interacting Partners?
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