CCHCR1 and ALAS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CCHCR1	ALAS1
Description		coiled-coil alpha-helical rod protein 1	5'-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Centriole Cytosol	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function		5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Protein Export From Nucleus Multicellular Organism Development Cell Differentiation	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Mitochondrion Organization Regulation Of Lipid Metabolic Process
Pathways			Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs			Pyridoxal Phosphate Pyridoxal Phosphate Glycine
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Feeling nervous ( 29500382) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Multiple myeloma ( 23955597) Nevirapine-induced rash ( 21810746) Night sleep phenotypes ( 27126917) Prostate cancer ( 21743467) Psoriasis ( 30921485) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) White blood cell count ( 21738480)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		62 interacting genes: ABI2 ALAS1 AMOTL2 ATG5 BLOC1S6 C1orf94 CARD9 CBY2 CCDC102B CCDC136 CDR2 CEP55 CNN1 COG6 EFHC2 FSD2 GLRX3 GOLGA2 GRAP2 HAUS1 HSBP1 HSPB1 IKBKG KRT13 KRT15 KRT31 KRT40 MAD1L1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NINL NME7 NUP62 NUTM1 PCM1 PIAS2 POLD2 POLR2C PRKCG RBM17 SAT1 SPAG5 SSX2IP STAR TADA2A TEKT1 TFIP11 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TSGA10 TXLNA TXLNB USHBP1 WASHC3 ZFYVE19	39 interacting genes: BCL7A C2orf42 C8orf33 CCHCR1 CDC73 CDK5 CDKN1A CERK EP400 GNL3L KLHL35 LONRF1 MTFR2 NUDT3 PIK3CB PLAU POLDIP2 PPL RAP1B RTL8B SH2D4A SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		54535	211
HPRD ID		05607	00505
Ensembl ID		ENSG00000204536	ENSG00000023330
Uniprot IDs		A0A1U9X7G6 Q2TB68 Q769H0 Q8TD31	B4DVA0 P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?
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