ATG5 and FADD

Number of citations of the paper that reports this interaction (PubMedID 15778222)
203

Data Source:
BioGRID (pull down, affinity chromatography technology, imaging technique)

		ATG5	FADD
Description		autophagy related 5	Fas associated via death domain
Image
GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytosol Axoneme Membrane Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated ER Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome
	Molecular Function	Protein Binding	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Receptor Serine/threonine Kinase Binding Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Caspase Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Blood Vessel Remodeling Regulation Of Cytokine Secretion Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Fungus Macroautophagy Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Autophagy Of Nucleus Negative Thymic T Cell Selection Otolith Development Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Negative Regulation Of Cell Death Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Autophagy Of Host Cells Involved In Interaction With Symbiont Regulation Of Cilium Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation	Kidney Development Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Toll-like Receptor 3 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Lymph Node Development Spleen Development Thymus Development Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Death-inducing Signaling Complex Assembly Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Macroautophagy Macroautophagy Pink/Parkin Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 27363682) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 31672989) Visceral fat ( 30942860)	Diverticular disease ( 30177863)
Interacting Genes		17 interacting genes: ATG10 ATG12 ATG16L1 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD KEAP1 MEOX2 OPTN RAB33B RACK1 TECPR1 TEKT4 VCP WDFY3	45 interacting genes: ABCA1 ANK3 ATG5 CASP10 CASP8 CASP8AP2 CFLAR CSNK1A1 DAP3 DAPK1 DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 PARK7 PEA15 PIDD1 PIN1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RYBP STAT1 STUB1 TAB1 TNFRSF10A TNFRSF10B TRADD TRAF2 TRIM21 XPO5
Entrez ID		9474	8772
HPRD ID		16051	03909
Ensembl ID		ENSG00000057663	ENSG00000168040
Uniprot IDs		A9UGY9 Q7Z3H3 Q9H1Y0	Q13158
PDB IDs		4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW	1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9 6ACI
Enriched GO Terms of Interacting Partners?
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