ATG5 and ATG16L1

Number of citations of the paper that reports this interaction (PubMedID 12665549)
256

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ATG5	ATG16L1
Description		autophagy related 5	autophagy related 16 like 1
Image
GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytosol Axoneme Membrane Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated ER Membrane	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane
	Molecular Function	Protein Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Blood Vessel Remodeling Regulation Of Cytokine Secretion Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Fungus Macroautophagy Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Autophagy Of Nucleus Negative Thymic T Cell Selection Otolith Development Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Negative Regulation Of Cell Death Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Autophagy Of Host Cells Involved In Interaction With Symbiont Regulation Of Cilium Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation	Autophagosome Assembly Protein Transport Macroautophagy Negative Stranded Viral RNA Replication
Pathways		Macroautophagy Macroautophagy Pink/Parkin Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	Macroautophagy Macroautophagy
Drugs
Diseases			Crohn's disease
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 27363682) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 31672989) Visceral fat ( 30942860)	Bilirubin levels ( 31319653) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		17 interacting genes: ATG10 ATG12 ATG16L1 CALCOCO2 CAPN1 CAPN2 CCHCR1 FADD KEAP1 MEOX2 OPTN RAB33B RACK1 TECPR1 TEKT4 VCP WDFY3	16 interacting genes: APP ATG12 ATG5 C3 CSNK2A1 CSNK2A2 GAN GIGYF2 NOD1 OPTN PLD3 RAB33A RAB33B SCAP TMEM59 UBC
Entrez ID		9474	55054
HPRD ID		16051	16498
Ensembl ID		ENSG00000057663	ENSG00000085978
Uniprot IDs		A9UGY9 Q7Z3H3 Q9H1Y0	A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5
PDB IDs		4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW	4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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