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ATG5 and ATG16L1
Number of citations of the paper that reports this interaction (PubMedID
12665549
)
256
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
ATG5
ATG16L1
Description
autophagy related 5
autophagy related 16 like 1
Image
GO Annotations
Cellular Component
Cytoplasm
Autophagosome
Cytosol
Axoneme
Membrane
Phagocytic Vesicle Membrane
Phagophore Assembly Site Membrane
Atg12-Atg5-Atg16 Complex
Mitochondria-associated ER Membrane
Autophagosome Membrane
Autophagosome
Cytosol
Axoneme
Phagophore Assembly Site Membrane
Molecular Function
Protein Binding
Protein Binding
Ubiquitin-like Protein Transferase Activity
Identical Protein Binding
GTPase Binding
Biological Process
Autophagosome Assembly
Autophagy Of Mitochondrion
Blood Vessel Remodeling
Regulation Of Cytokine Secretion Involved In Immune Response
C-terminal Protein Lipidation
Autophagy
Apoptotic Process
Cellular Response To Nitrogen Starvation
Response To Fungus
Macroautophagy
Antigen Processing And Presentation Of Endogenous Antigen
Negative Regulation Of Protein Ubiquitination
Aggrephagy
Negative Stranded Viral RNA Replication
Vasodilation
Response To Drug
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Autophagy Of Nucleus
Negative Thymic T Cell Selection
Otolith Development
Negative Regulation Of Phagocytosis
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Ventricular Cardiac Muscle Cell Development
Heart Contraction
Negative Regulation Of Cell Death
Protein Lipidation Involved In Autophagosome Assembly
Positive Regulation Of Mucus Secretion
Cellular Response To Nitrosative Stress
Autophagy Of Host Cells Involved In Interaction With Symbiont
Regulation Of Cilium Assembly
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Histone H4-K16 Acetylation
Autophagosome Assembly
Protein Transport
Macroautophagy
Negative Stranded Viral RNA Replication
Pathways
Macroautophagy
Macroautophagy
Pink/Parkin Mediated Mitophagy
Receptor Mediated Mitophagy
Negative regulators of DDX58/IFIH1 signaling
Macroautophagy
Macroautophagy
Drugs
Diseases
Crohn's disease
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Glucose homeostasis traits (
25524916
)
Limited cutaneous systemic scleroderma (
24387989
)
Monobrow (
27182965
)
Multiple myeloma (
27363682
)
Rheumatoid arthritis (
30423114
24390342
)
Systemic lupus erythematosus (
27399966
23273568
26502338
28714469
19838193
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Systemic sclerosis (
24387989
31672989
)
Visceral fat (
30942860
)
Bilirubin levels (
31319653
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
20570966
22936669
22412388
17435756
17554300
21102463
23128233
)
Inflammatory bowel disease (
28067908
)
Pediatric autoimmune diseases (
26301688
)
Interacting Genes
17 interacting genes:
ATG10
ATG12
ATG16L1
CALCOCO2
CAPN1
CAPN2
CCHCR1
FADD
KEAP1
MEOX2
OPTN
RAB33B
RACK1
TECPR1
TEKT4
VCP
WDFY3
16 interacting genes:
APP
ATG12
ATG5
C3
CSNK2A1
CSNK2A2
GAN
GIGYF2
NOD1
OPTN
PLD3
RAB33A
RAB33B
SCAP
TMEM59
UBC
Entrez ID
9474
55054
HPRD ID
16051
16498
Ensembl ID
ENSG00000057663
ENSG00000085978
Uniprot IDs
A9UGY9
Q7Z3H3
Q9H1Y0
A0A024R494
A0A024R4B6
Q17RG0
Q53SV2
Q676U5
PDB IDs
4GDK
4GDL
4NAW
4TQ0
4TQ1
5D7G
5NPV
5NPW
4GDK
4GDL
4NAW
4TQ0
5D7G
5NPV
5NPW
5NUV
5ZYX
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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