TNFRSF8 and TRAF5

Number of citations of the paper that reports this interaction (PubMedID 8999898)
41

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		TNFRSF8	TRAF5
Description		TNF receptor superfamily member 8	TNF receptor associated factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of TRAIL Biosynthetic Process Cellular Response To Mechanical Stimulus	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination
Pathways		TNFs bind their physiological receptors
Drugs		Brentuximab vedotin
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)	Household income (MTAG) ( 31844048)
Interacting Genes		7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5	45 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GOLGA2 GORASP2 HSD17B10 LTBR MAP3K14 MAP3K5 MDM2 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TBK1 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 ZFAND6
Entrez ID		943	7188
HPRD ID		01074	03834
Ensembl ID		ENSG00000120949	ENSG00000082512
Uniprot IDs		A5D8T4 P28908	O00463
PDB IDs		1D01
Enriched GO Terms of Interacting Partners?
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