TRAF5 and THAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRAF5	THAP1
Description		TNF receptor associated factor 5	THAP domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Receptor Complex	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Mitotic Cell Cycle
Pathways
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Household income (MTAG) ( 31844048)	Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		45 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GOLGA2 GORASP2 HSD17B10 LTBR MAP3K14 MAP3K5 MDM2 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TBK1 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 ZFAND6	65 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BMS1P1 BYSL C1orf35 C7orf50 CHD2 CSNK2A1 DCAF8 DVL2 EEF1AKNMT FAM124A FAM133A FXR2 GOLGA7 GPATCH2L HNRNPLL KLF12 KRTAP10-7 LASP1 MORF4L1 MORF4L2 MRPL11 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PID1 POLR2L POLR2M PPIG PRKAA1 PRR20A QKI RALYL RBM10 RBM39 RIPPLY1 RP9P RPS25 SAP30BP SERF2 SLU7 STRBP TCEA2 TPM3 TRAF5 TRIM26 TTLL10 TXN2 U2AF2 WT1 YES1 ZCCHC10 ZNF385C ZNF408
Entrez ID		7188	55145
HPRD ID		03834	15496
Ensembl ID		ENSG00000082512	ENSG00000131931
Uniprot IDs		O00463	Q9NVV9
PDB IDs			2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?
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