TNFRSF8 and TNFSF8

Number of citations of the paper that reports this interaction (PubMedID 11754357)
13

Data Source:
HPRD (in vitro)

		TNFRSF8	TNFSF8
Description		TNF receptor superfamily member 8	TNF superfamily member 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of TRAIL Biosynthetic Process Cellular Response To Mechanical Stimulus	Immune Response Cell-cell Signaling Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs		Brentuximab vedotin
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 30500874 21102463 23266558) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) IgA levels ( 28628107) Inflammatory bowel disease ( 27569725 23128233) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 30643196) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 21297633)
Interacting Genes		7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5	2 interacting genes: ANG TNFRSF8
Entrez ID		943	944
HPRD ID		01074	04852
Ensembl ID		ENSG00000120949	ENSG00000106952
Uniprot IDs		A5D8T4 P28908	A0A087X228 P32971 Q52M88
PDB IDs		1D01
Enriched GO Terms of Interacting Partners?
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