TRAF5 and TNFRSF11A

Number of citations of the paper that reports this interaction (PubMedID 9774460)
104

Data Source:
HPRD (in vitro)

		TRAF5	TNFRSF11A
Description		TNF receptor associated factor 5	TNF receptor superfamily member 11a
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Receptor Complex	Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination	Ossification Adaptive Immune Response Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Response To Radiation Osteoclast Differentiation Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Tumor Necrosis Factor Positive Regulation Of JUN Kinase Activity Positive Regulation Of Bone Resorption Lymph Node Development Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Circadian Temperature Homeostasis Mammary Gland Alveolus Development Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Multinuclear Osteoclast Differentiation
Pathways			TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases			Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD) Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Household income (MTAG) ( 31844048)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576 29875488) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Myasthenia gravis ( 25643325) Paget's disease ( 21623375 20436471) Response to antipsychotic treatment ( 23241943) Serum albumin level ( 23022100) Serum alkaline phosphatase levels ( 29403010) Vitiligo ( 27723757)
Interacting Genes		45 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GOLGA2 GORASP2 HSD17B10 LTBR MAP3K14 MAP3K5 MDM2 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TBK1 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 ZFAND6	14 interacting genes: CBL CBLB ETFA FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		7188	8792
HPRD ID		03834	04609
Ensembl ID		ENSG00000082512	ENSG00000141655
Uniprot IDs		O00463	Q9Y6Q6
PDB IDs			1LB5
Enriched GO Terms of Interacting Partners?
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