CD27 and TRAF5

Number of citations of the paper that reports this interaction (PubMedID 9582383)
55

Data Source:
HPRD (in vivo)

		CD27	TRAF5
Description		CD27 molecule	TNF receptor associated factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Plasma Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Crohn's disease ( 26192919)	Household income (MTAG) ( 31844048)
Interacting Genes		7 interacting genes: ACTN2 CD70 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2	45 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GOLGA2 GORASP2 HSD17B10 LTBR MAP3K14 MAP3K5 MDM2 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TBK1 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 ZFAND6
Entrez ID		939	7188
HPRD ID		01723	03834
Ensembl ID		ENSG00000139193	ENSG00000082512
Uniprot IDs		P26842	O00463
PDB IDs		5TL5 5TLJ 5TLK
Enriched GO Terms of Interacting Partners?
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