CD3E and CD3D

Number of citations of the paper that reports this interaction (PubMedID 9485181)
21

Data Source:
HPRD (in vivo, in vitro)

		CD3E	CD3D
Description		CD3e molecule	CD3d molecule
Image
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Dendritic Spine Cell Body	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Identical Protein Binding Protein Heterodimerization Activity	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of T Cell Anergy Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Response To Nutrient Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cerebellum Development T Cell Differentiation T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Apoptotic Signaling Pathway	Adaptive Immune Response Cell Surface Receptor Signaling Pathway T Cell Differentiation Positive Thymic T Cell Selection Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Muromonab	Muromonab Blinatumomab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)	Pulse pressure ( 27841878)
Interacting Genes		20 interacting genes: CD3D CD3EAP CD3G CD79B CSK EPS8L1 LCK NCK1 NCK2 NCL PIK3R1 PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UNC119 ZAP70	11 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 TRA TRB
Entrez ID		916	915
HPRD ID		08923	01730
Ensembl ID		ENSG00000198851	ENSG00000167286
Uniprot IDs		P07766	B0YIY4 P04234
PDB IDs		1A81 1SY6 1XIW 2ROL 6JXR	1XIW 6JXR
Enriched GO Terms of Interacting Partners?
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