CD3D and CD8A

Number of citations of the paper that reports this interaction (PubMedID 12215456)
26

Data Source:
HPRD (in vivo, in vitro)

		CD3D	CD8A
Description		CD3d molecule	CD8a molecule
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway T Cell Differentiation Positive Thymic T Cell Selection Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization	T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Muromonab Blinatumomab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Pulse pressure ( 27841878)	Blood protein levels ( 30072576)
Interacting Genes		11 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 TRA TRB	19 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 GGCX HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 MRPS5 PTPRC SREK1 SRSF1
Entrez ID		915	925
HPRD ID		01730	01737
Ensembl ID		ENSG00000167286	ENSG00000153563
Uniprot IDs		B0YIY4 P04234	P01732 Q6ZVS2 Q8TAW8
PDB IDs		1XIW 6JXR	1AKJ 1CD8 1Q69 2HP4 3QZW
Enriched GO Terms of Interacting Partners?
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