CD3D and CD8B

Number of citations of the paper that reports this interaction (PubMedID 12215456)
26

Data Source:
HPRD (in vivo)

		CD3D	CD8B
Description		CD3d molecule	CD8b molecule
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Early Endosome Membrane T Cell Receptor Complex
	Molecular Function	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity	Protein Binding Coreceptor Activity MHC Class I Protein Binding
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway T Cell Differentiation Positive Thymic T Cell Selection Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization	Adaptive Immune Response Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Activation Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Nef Mediated CD8 Down-regulation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Muromonab Blinatumomab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Pulse pressure ( 27841878)	Progressive supranuclear palsy ( 21685912)
Interacting Genes		11 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 TRA TRB	4 interacting genes: CD3D CD8A MRPS5 ST3GAL4
Entrez ID		915	926
HPRD ID		01730	01725
Ensembl ID		ENSG00000167286	ENSG00000172116
Uniprot IDs		B0YIY4 P04234	P10966 Q53QL8
PDB IDs		1XIW 6JXR
Enriched GO Terms of Interacting Partners?
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