CD3D and HERPUD1

Number of citations of the paper that reports this interaction (PubMedID 18307982)
35

Data Source:
HPRD (in vivo)

		CD3D	HERPUD1
Description		CD3d molecule	homocysteine inducible ER protein with ubiquitin like domain 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Lewy Body Core
	Molecular Function	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity	Molecular_function Protein Binding Ion Channel Binding Protein Binding, Bridging Involved In Substrate Recognition For Ubiquitination
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway T Cell Differentiation Positive Thymic T Cell Selection Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	ATF4 activates genes in response to endoplasmic reticulum stress
Drugs		Muromonab Blinatumomab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Pulse pressure ( 27841878)	Cardiovascular risk factors ( 20838585) Coronary artery disease ( 29212778) Diisocyanate-induced asthma ( 25918132) HDL cholesterol ( 20031564 23505323 24886709) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) LDL cholesterol levels ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low HDL-cholesterol levels ( 31910446) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Total cholesterol levels ( 29403010) Triglyceride levels ( 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		11 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 TRA TRB	16 interacting genes: AMFR APP ARHGDIA CD3D CD58 EWSR1 IMPA2 PSEN1 RPA2 SH3RF1 STARD9 TOLLIP UBQLN2 USP7 VCP XRCC6
Entrez ID		915	9709
HPRD ID		01730	07456
Ensembl ID		ENSG00000167286	ENSG00000051108
Uniprot IDs		B0YIY4 P04234	A4UAE9 Q15011 Q53FP9
PDB IDs		1XIW 6JXR	1WGD
Enriched GO Terms of Interacting Partners?
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