CD3D and TRA

Number of citations of the paper that reports this interaction (PubMedID 8020575)
23

Data Source:
HPRD (in vivo, in vitro)

		CD3D	TRA
Description		CD3d molecule	T cell receptor alpha locus
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway T Cell Differentiation Positive Thymic T Cell Selection Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Muromonab Blinatumomab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Pulse pressure ( 27841878)	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		11 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 TRA TRB	15 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD
Entrez ID		915	6955
HPRD ID		01730	01736
Ensembl ID		ENSG00000167286
Uniprot IDs		B0YIY4 P04234
PDB IDs		1XIW 6JXR
Enriched GO Terms of Interacting Partners?
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