CD8A and SRSF1

Number of citations of the paper that reports this interaction (PubMedID 10022843)
57

Data Source:
HPRD (in vitro)

		CD8A	SRSF1
Description		CD8a molecule	serine and arginine rich splicing factor 1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex Plasma Membrane Raft	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding
	Biological Process	T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs			Copper
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Blood protein levels ( 30072576)
Interacting Genes		19 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 GGCX HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 MRPS5 PTPRC SREK1 SRSF1	40 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		925	6426
HPRD ID		01737	02887
Ensembl ID		ENSG00000153563	ENSG00000136450
Uniprot IDs		P01732 Q6ZVS2 Q8TAW8	Q07955 Q59FA2
PDB IDs		1AKJ 1CD8 1Q69 2HP4 3QZW	1X4A 2M7S 2M8D 2O3D 3BEG 4C0O
Enriched GO Terms of Interacting Partners?
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