CD8A and CD8B

Number of citations of the paper that reports this interaction (PubMedID 10809759)
35

Data Source:
BioGRID (imaging technique)
HPRD (in vivo, in vitro)

		CD8A	CD8B
Description		CD8a molecule	CD8b molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane T Cell Receptor Complex Plasma Membrane Raft	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Early Endosome Membrane T Cell Receptor Complex
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Complex Binding MHC Class I Protein Binding	Protein Binding Coreceptor Activity MHC Class I Protein Binding
	Biological Process	T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation T Cell Activation Cytotoxic T Cell Differentiation Regulation Of Immune Response	Adaptive Immune Response Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Activation Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Nef Mediated CD8 Down-regulation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Blood protein levels ( 30072576)	Progressive supranuclear palsy ( 21685912)
Interacting Genes		19 interacting genes: B2M CACYBP CD3D CD59 CD8B CDK1 GGCX HLA-A HLA-B HLA-C HLA-E HLA-G LAT LCK LGALS1 MRPS5 PTPRC SREK1 SRSF1	4 interacting genes: CD3D CD8A MRPS5 ST3GAL4
Entrez ID		925	926
HPRD ID		01737	01725
Ensembl ID		ENSG00000153563	ENSG00000172116
Uniprot IDs		P01732 Q6ZVS2 Q8TAW8	P10966 Q53QL8
PDB IDs		1AKJ 1CD8 1Q69 2HP4 3QZW
Enriched GO Terms of Interacting Partners?
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