LHX4 and TCAP

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		LHX4	TCAP
Description		LIM homeobox 4	titin-cap
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Cytosol Z Disc I Band
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Structural Constituent Of Muscle Protein Binding, Bridging Titin Binding BMP Binding Ion Channel Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Cardiac Muscle Fiber Development Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Protein-containing Complex Assembly
Pathways		Regulation of expression of SLITs and ROBOs	Striated Muscle Contraction
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Limb-girdle muscular dystrophy (LGMD)
GWAS			Alcohol consumption ( 31358974) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Ulcerative colitis ( 20228799)
Interacting Genes		22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2	17 interacting genes: ANKRD2 ATXN1 CRK FAS FYN HSPB2 LHX4 MDM2 MSTN MYOZ1 MYOZ3 PDPK1 RELA SIVA1 TRIM55 TRIM63 TTN
Entrez ID		89884	8557
HPRD ID		03686	05133
Ensembl ID		ENSG00000121454	ENSG00000173991
Uniprot IDs		A0A0S2Z5S4 Q969G2	A2TDC0 O15273
PDB IDs		5HOD	1YA5 2F8V
Enriched GO Terms of Interacting Partners?
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