LHX4 and NRF1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		LHX4	NRF1
Description		LIM homeobox 4	nuclear respiratory factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity
	Biological Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of expression of SLITs and ROBOs	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2	13 interacting genes: CSNK2A1 DYNLL1 FHL2 LHX4 MAFF PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SP4 TRAF2
Entrez ID		89884	4899
HPRD ID		03686	02930
Ensembl ID		ENSG00000121454	ENSG00000106459
Uniprot IDs		A0A0S2Z5S4 Q969G2	A0A024R770 A0A024R774 Q16656
PDB IDs		5HOD
Enriched GO Terms of Interacting Partners?
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