LHX4 and FDX2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LHX4	FDX2
Description		LIM homeobox 4	ferredoxin 2
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Mitochondrial Matrix
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	C21-steroid Hormone Biosynthetic Process Sterol Metabolic Process Electron Transport Chain Small Molecule Metabolic Process
Pathways		Regulation of expression of SLITs and ROBOs	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Interacting Genes		22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2	2 interacting genes: APP LHX4
Entrez ID		89884	112812
HPRD ID		03686	14465
Ensembl ID		ENSG00000121454	ENSG00000267673
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q6P4F2
PDB IDs		5HOD	2Y5C
Enriched GO Terms of Interacting Partners?
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