LHX4 and CHCHD2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LHX4	CHCHD2
Description		LIM homeobox 4	coiled-coil-helix-coiled-coil-helix domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleus Mitochondrion Mitochondrial Intermembrane Space
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Hypoxia
Pathways		Regulation of expression of SLITs and ROBOs	Mitochondrial protein import
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Metabolite levels ( 23823483 31628463) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
Interacting Genes		22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2	13 interacting genes: ADAMTSL4 EHMT2 FBXO7 GOLGA2 IKZF3 INCA1 KRT31 KRT40 LHX4 REL TCF4 TREX1 TRIM54
Entrez ID		89884	51142
HPRD ID		03686	09879
Ensembl ID		ENSG00000121454	ENSG00000106153
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q9Y6H1
PDB IDs		5HOD
Enriched GO Terms of Interacting Partners?
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