EIF3C and HMOX2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		EIF3C	HMOX2
Description		eukaryotic translation initiation factor 3 subunit C	heme oxygenase 2
Image
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Cell Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Heme degradation Neutrophil degranulation Iron uptake and transport
Drugs			NADH Stannsoporfin
Diseases
GWAS		Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574)	Erectile dysfunction ( 30583798)
Interacting Genes		17 interacting genes: AAGAB ALKBH4 BCKDK CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 TACC3	35 interacting genes: A2M APP ATP5F1B BLOC1S2 CEBPZ CEP126 COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 LMNA LRIF1 MARK3 MED31 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746
Entrez ID		8663	3163
HPRD ID		04889	00783
Ensembl ID		ENSG00000184110	ENSG00000103415
Uniprot IDs		A0A024QYU9 Q99613	A0A087WT44 B3KSE0 P30519
PDB IDs		3J8B 3J8C	2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?
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