EIF3C and TACC3

Number of citations of the paper that reports this interaction (PubMedID 30217970)
1

Data Source:
BioGRID (two hybrid)

		EIF3C	TACC3
Description		eukaryotic translation initiation factor 3 subunit C	transforming acidic coiled-coil containing protein 3
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Spindle Pole Cytoplasm Cytosol Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding	Protein Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Cell Proliferation Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS		Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574)	Bladder cancer ( 24163127 20972438) Urinary bladder cancer ( 20348956)
Interacting Genes		17 interacting genes: AAGAB ALKBH4 BCKDK CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 TACC3	16 interacting genes: AKAP9 ARNT ARNT2 ASPSCR1 AURKA CIB3 CLIP4 EIF3C KAT2A KIZ NDEL1 NOD2 SNX20 TBC1D22B TTF2 VPS37C
Entrez ID		8663	10460
HPRD ID		04889	05601
Ensembl ID		ENSG00000184110	ENSG00000013810
Uniprot IDs		A0A024QYU9 Q99613	Q9Y6A5
PDB IDs		3J8B 3J8C	5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?
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