NPRL3 and FHL3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NPRL3	FHL3
Description		NPR3 like, GATOR1 complex subunit	four and a half LIM domains 3
Image
GO Annotations	Cellular Component	Lysosomal Membrane GATOR1 Complex	Stress Fiber Nucleus Focal Adhesion Z Disc
	Molecular Function	GTPase Activator Activity Protein Binding	Transcription Coregulator Activity Actin Binding Protein Binding Metal Ion Binding
	Biological Process	Ventricular Septum Development Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Aorta Morphogenesis TORC1 Signaling Positive Regulation Of GTPase Activity Cardiac Muscle Tissue Development Roof Of Mouth Development Regulation Of Autophagosome Assembly	Muscle Organ Development Actin Cytoskeleton Organization Regulation Of Nucleic Acid-templated Transcription
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Hemoglobin levels ( 26366553) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin ( 29403010 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 28453575 27863252) Red blood cell count ( 29403010 27863252) Red blood cell traits ( 23446634 23222517) Reticulocyte fraction of red cells ( 27863252) Sickle cell anemia (haemolysis) ( 23406172)	Coronary artery disease ( 29212778) Pulse pressure ( 30578418)
Interacting Genes		3 interacting genes: APPBP2 FHL3 SESN3	125 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 C9orf116 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CLCN2 CNNM3 CNOT7 CORO1A CSF1 CTBP2 DCDC2B E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 EXOSC1 EXOSC5 FAM126A FAM71C FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GATA1 GATA2 GCM2 HIPK1 HYAL2 IHO1 IKZF3 ITGA7 KIRREL2 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LMO2 LNX1 LNX2 MAPK1 MED15 MORF4L1 MPZL1 MRM3 MRPL27 MTA1 MTUS2 MYBPC1 MYBPHL MZF1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PLEKHF2 PLEKHG4B PPIG PTPN6 QKI QRICH1 RAB40B RAD21 RBM42 RFX3 RFX6 RHEBL1 RYBP SAP30BP SAXO1 SH3GLB2 SLAIN1 SLC25A46 SLC44A3 SMAD2 SMAD3 SMAD4 SNRPG SPATA8 SREBF2 SRF SRGN SUPT5H THEG TLE5 TMEM14B TMX3 TOPBP1 TRAF3IP2 TRIM27 TRIP6 TRO TTLL10 TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WNK1 YPEL3 ZFP36 ZNF417 ZNF512B ZNRD1
Entrez ID		8131	2275
HPRD ID		11866	09101
Ensembl ID		ENSG00000103148	ENSG00000183386
Uniprot IDs		B7Z220 B7Z6Q0 Q12980 Q9BTE2	Q13643 Q96C98
PDB IDs		6CES 6CET	1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?