NPRL3 and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NPRL3	APPBP2
Description		NPR3 like, GATOR1 complex subunit	amyloid beta precursor protein binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane GATOR1 Complex	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Ventricular Septum Development Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Aorta Morphogenesis TORC1 Signaling Positive Regulation Of GTPase Activity Cardiac Muscle Tissue Development Roof Of Mouth Development Regulation Of Autophagosome Assembly	Intracellular Protein Transport Intracellular Transport
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Hemoglobin levels ( 26366553) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin ( 29403010 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 28453575 27863252) Red blood cell count ( 29403010 27863252) Red blood cell traits ( 23446634 23222517) Reticulocyte fraction of red cells ( 27863252) Sickle cell anemia (haemolysis) ( 23406172)	Waist-hip ratio ( 28552196)
Interacting Genes		3 interacting genes: APPBP2 FHL3 SESN3	81 interacting genes: - AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 CYBA DCD DHRS2 DPEP1 EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 H2AC15 HIPK4 HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		8131	10513
HPRD ID		11866	05616
Ensembl ID		ENSG00000103148	ENSG00000062725
Uniprot IDs		B7Z220 B7Z6Q0 Q12980 Q9BTE2	A0A024QZ47 Q92624
PDB IDs		6CES 6CET
Enriched GO Terms of Interacting Partners?
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