FHL3 and CNOT7

Number of citations of the paper that reports this interaction (PubMedID 30217970)
1

Data Source:
BioGRID (two hybrid)

		FHL3	CNOT7
Description		four and a half LIM domains 3	CCR4-NOT transcription complex subunit 7
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GO Annotations	Cellular Component	Stress Fiber Nucleus Focal Adhesion Z Disc	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex Host Cell PML Body
	Molecular Function	Transcription Coregulator Activity Actin Binding Protein Binding Metal Ion Binding	3'-5'-exoribonuclease Activity Transcription Corepressor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Muscle Organ Development Actin Cytoskeleton Organization Regulation Of Nucleic Acid-templated Transcription	Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Translation Gene Silencing By RNA Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Regulation Of Tyrosine Phosphorylation Of STAT Protein Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Pulse pressure ( 30578418)
Interacting Genes		125 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 C9orf116 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CLCN2 CNNM3 CNOT7 CORO1A CSF1 CTBP2 DCDC2B E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 EXOSC1 EXOSC5 FAM126A FAM71C FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GATA1 GATA2 GCM2 HIPK1 HYAL2 IHO1 IKZF3 ITGA7 KIRREL2 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LMO2 LNX1 LNX2 MAPK1 MED15 MORF4L1 MPZL1 MRM3 MRPL27 MTA1 MTUS2 MYBPC1 MYBPHL MZF1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PLEKHF2 PLEKHG4B PPIG PTPN6 QKI QRICH1 RAB40B RAD21 RBM42 RFX3 RFX6 RHEBL1 RYBP SAP30BP SAXO1 SH3GLB2 SLAIN1 SLC25A46 SLC44A3 SMAD2 SMAD3 SMAD4 SNRPG SPATA8 SREBF2 SRF SRGN SUPT5H THEG TLE5 TMEM14B TMX3 TOPBP1 TRAF3IP2 TRIM27 TRIP6 TRO TTLL10 TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WNK1 YPEL3 ZFP36 ZNF417 ZNF512B ZNRD1	29 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI PABPC1 PIAS1 PSMC1 PSMC2 RAD54L2 SCARA3 SH3GLB2 TEX11 TNRC6A TOB1 TOB2 TSG101
Entrez ID		2275	29883
HPRD ID		09101	05370
Ensembl ID		ENSG00000183386	ENSG00000198791
Uniprot IDs		Q13643 Q96C98	Q96IQ6 Q9UIV1
PDB IDs		1WYH 2CUQ 2EHE	2D5R 4GMJ
Enriched GO Terms of Interacting Partners?
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