FHL3 and CHEK2

Number of citations of the paper that reports this interaction (PubMedID 28094252)
18

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		FHL3	CHEK2
Description		four and a half LIM domains 3	checkpoint kinase 2
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Focal Adhesion Z Disc	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body
	Molecular Function	Transcription Coregulator Activity Actin Binding Protein Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Muscle Organ Development Actin Cytoskeleton Organization Regulation Of Nucleic Acid-templated Transcription	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Replicative Cell Aging Positive Regulation Of Protein Phosphorylation Double-strand Break Repair Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Peptidyl-serine Phosphorylation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Protein Catabolic Process Mitotic DNA Damage Checkpoint Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Negative Regulation Of Cell Cycle Arrest Cellular Response To Gamma Radiation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs			XL844
Diseases			Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS		Coronary artery disease ( 29212778) Pulse pressure ( 30578418)	Breast cancer ( 29059683 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Lung cancer ( 24880342) Menopause (age at onset) ( 26414677) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 28957414) Vertical cup-disc ratio ( 20548946 31798171 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		125 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 C9orf116 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CLCN2 CNNM3 CNOT7 CORO1A CSF1 CTBP2 DCDC2B E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 EXOSC1 EXOSC5 FAM126A FAM71C FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GATA1 GATA2 GCM2 HIPK1 HYAL2 IHO1 IKZF3 ITGA7 KIRREL2 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LMO2 LNX1 LNX2 MAPK1 MED15 MORF4L1 MPZL1 MRM3 MRPL27 MTA1 MTUS2 MYBPC1 MYBPHL MZF1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PLEKHF2 PLEKHG4B PPIG PTPN6 QKI QRICH1 RAB40B RAD21 RBM42 RFX3 RFX6 RHEBL1 RYBP SAP30BP SAXO1 SH3GLB2 SLAIN1 SLC25A46 SLC44A3 SMAD2 SMAD3 SMAD4 SNRPG SPATA8 SREBF2 SRF SRGN SUPT5H THEG TLE5 TMEM14B TMX3 TOPBP1 TRAF3IP2 TRIM27 TRIP6 TRO TTLL10 TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WNK1 YPEL3 ZFP36 ZNF417 ZNF512B ZNRD1	79 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 GNAS HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 POLR2L PPM1D PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP TLR3 TP53 TSSK1B VHL
Entrez ID		2275	11200
HPRD ID		09101	05084
Ensembl ID		ENSG00000183386	ENSG00000183765
Uniprot IDs		Q13643 Q96C98	O96017
PDB IDs		1WYH 2CUQ 2EHE	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?
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