TCL1A and LSM3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TCL1A	LSM3
Description		T cell leukemia/lymphoma 1A	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	Multicellular Organism Development Positive Regulation Of Cell Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity	MRNA Splicing, Via Spliceosome MRNA Processing Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)	Chronotype ( 30696823) Height ( 31562340) Offspring birth weight ( 31043758)
Interacting Genes		23 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CEP55 DNMT3A FLACC1 GOLGA2 H2AW LNX2 LSM3 NTAQ1 PRTFDC1 TCF4 TP53BP2 TRAF1 TTC33 TXLNA TXLNB WDR47	40 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 KEAP1 KLF3 LSM1 LSM10 LSM2 LSM5 LSM6 LSM7 LSM8 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPG TCL1A TFIP11 THOC5 UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		8115	27258
HPRD ID		01744	06283
Ensembl ID		ENSG00000100721	ENSG00000170860
Uniprot IDs		A0A024R6G5 P56279	P62310
PDB IDs		1JSG	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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