TCL1A and AKT3

Number of citations of the paper that reports this interaction (PubMedID 11707444)
27

Data Source:
HPRD (in vitro, in vivo)

		TCL1A	AKT3
Description		T cell leukemia/lymphoma 1A	AKT serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex	Nucleus Cytoplasm Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Multicellular Organism Development Positive Regulation Of Cell Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity	Mitochondrial Genome Maintenance Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Signal Transduction Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of Cellular Senescence
Pathways			Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)	Adventurousness ( 30643258) Antisaccade task score ( 31596458) Diabetic retinopathy ( 21441570) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Height ( 28552196) Menarche (age at onset) ( 23599027) Non-glioblastoma glioma ( 28346443) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Self-reported risk-taking behaviour ( 30181555)
Interacting Genes		23 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CEP55 DNMT3A FLACC1 GOLGA2 H2AW LNX2 LSM3 NTAQ1 PRTFDC1 TCF4 TP53BP2 TRAF1 TTC33 TXLNA TXLNB WDR47	11 interacting genes: FBXO7 GSK3B IWS1 NEDD4 NEDD4L PDPK1 PPP2CA PRKCD PRKCZ TCL1A TSC2
Entrez ID		8115	10000
HPRD ID		01744	06441
Ensembl ID		ENSG00000100721	ENSG00000117020
Uniprot IDs		A0A024R6G5 P56279	A0A5F9ZHU3 Q9Y243
PDB IDs		1JSG	2X18
Enriched GO Terms of Interacting Partners?
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