ZBP1 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZBP1	KLHL12
Description		Z-DNA binding protein 1	kelch like family member 12
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Left-handed Z-DNA Binding Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Biological_process Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN RIP-mediated NFkB activation via ZBP1 Regulation of innate immune responses to cytosolic DNA	Degradation of DVL
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075) Verbal declarative memory ( 25648963)
Interacting Genes		8 interacting genes: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6	46 interacting genes: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL2 DVL3 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 MTNR1A NDC80 NTAQ1 PDGFRB PEA15 PEF1 PRR13 RIT1 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 ZBP1
Entrez ID		81030	59349
HPRD ID		09484	13925
Ensembl ID		ENSG00000124256	ENSG00000117153
Uniprot IDs		Q9H171	Q53G59 Q9H7R2
PDB IDs		2L4M 2LNB 3EYI 4KA4	2VPJ
Enriched GO Terms of Interacting Partners?
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