ZBP1 and PLXDC2

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ZBP1	PLXDC2
Description		Z-DNA binding protein 1	plexin domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Integral Component Of Membrane
	Molecular Function	DNA Binding Left-handed Z-DNA Binding Protein Binding	Protein Binding
	Biological Process	Biological_process Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN RIP-mediated NFkB activation via ZBP1 Regulation of innate immune responses to cytosolic DNA
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075) Verbal declarative memory ( 25648963)	Abdominal aortic calcification levels ( 31659325) Activated partial thromboplastin time ( 29403010) Blood protein levels ( 30072576 29875488 28240269) Bone mineral density (Ward's triangle area) ( 27397699) Bronchopulmonary dysplasia ( 23897914) Diabetic retinopathy ( 21310492) Hair color ( 26926045) Heel bone mineral density ( 30598549 28869591) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Photic sneeze reflex ( 27182965) Plasma factor V levels in venous thrombosis ( 31271701) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Proteinuria and chronic kidney disease ( 26420894) Prothrombin time ( 29403010) Pulse pressure ( 27841878 30578418)
Interacting Genes		8 interacting genes: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6	2 interacting genes: CLK1 ZBP1
Entrez ID		81030	84898
HPRD ID		09484	08440
Ensembl ID		ENSG00000124256	ENSG00000120594
Uniprot IDs		Q9H171	Q6UX71
PDB IDs		2L4M 2LNB 3EYI 4KA4
Enriched GO Terms of Interacting Partners?
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